Elucidation of DnaE as the Antibacterial Target of the Natural Product, Nargenicin
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- 作者：Ronald E. Painter4 ; Gregory C. Adam2 ; Marta Arocho3 ; Edward DiNunzio4 ; Robert G.K. Donald1 ; Karen Dorso1 ; Olga Genilloud6 ; 7 ; Charles Gill1 ; Michael Goetz3 ; 8 ; Nichelle N. Hairston1 ; Nicholas Murgolo5 ; Bakela Nare1 ; David B. Olsen1 ; Maryann Powles1 ; Fred Racine1 ; Jing Su3 ; Francisca Vicente6 ; 7 ; Douglas Wisniewski1 ; Li Xiao3 ; Milton Hammond1 ; Katherine Young1 ; katherine_young@merck.com" class="auth_mail" title="E-mail the corresponding author
- 刊名：Chemistry & Biology
- 出版年：2015
- 出版时间：22 October 2015
- 年：2015
- 卷：22
- 期：10
- 页码：1362-1373
- 全文大小：2036 K
文摘
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Nargenicin inhibited DNA synthesis in macromolecular labeling studies
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Resistance mutation mapped to dnaE and was necessary and sufficient for resistance
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Nargenicin inhibited a DnaE single-enzyme assay
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DNA promoted binding of nargenicin to S. aureus DnaE but not E. coli DnaE