Genetic variation at 鈭?#xa0;1878 (rs2596542) in MICA gene region is associated with chronic hepatitis B virus infection in Saudi Arabian patients
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- 作者：Ahmed A. Al-Qahtani ; Mashael Al-Anazi ; Ayman A. Abdo ; Faisal M. Sanai ; Waleed Al-Hamoudi ; Khalid A. Alswat ; Hamad I. Al-Ashgar ; Nisreen Khalaf ; Nisha Viswan ; Mohammed N. Al-Ahdal
- 关键词：Single nucleotide polymorphism ; HBV ; HCC ; MICA ; Saudi Arabia
- 刊名：Experimental and Molecular Pathology
- 出版年：December, 2013
- 年：2013
- 卷：95
- 期：3
- 页码：255-258
- 全文大小：222 K
文摘
MHC class I polypeptide-related chain A (MICA), mapping to 6p21.33, belongs to the non-classical class I family and its expression is induced by several stress factors including viral infection. A recent genome-wide association study has identified a single nucleotide polymorphism (SNP) of MICA, rs2596542 to be significantly associated with hepatitis C-induced hepatocellular carcinoma (HCC) in a Japanese population. Therefore, this study aims to investigate whether the SNP rs2596542 plays any role in hepatitis B virus (HBV) sero-clearance or in the development of complications associated with chronic HBV such as cirrhosis and/or HCC. TaqMan genotyping assay was used to identify the association of the SNP among 584 normal healthy controls and 777 HBV-infected patients. The patient group was further categorized into inactive carriers (Group I), active carriers (Group II), cirrhosis (Group III) and cirrhosis-HCC (Group IV). Variation at this SNP was found to be significantly more frequent in control subjects than in patients (OR = 0.852; 95% C.I. = 0.730-0.994; p = 0.0415). Also, the SNP was found to have a highly significant association when the inactive carriers were compared to the rest of the patients (OR = 1.308; 95% C.I. = 1.058-1.617; p = 0.0130). The TT genotype was found to occur more frequently among active HBV carriers (groups II, III and IV) when compared to inactive HBV carriers, thus suggesting that the rs2596542-T may be recessively associated with an active HBV infection. However, no significant association was observed in the case of HBV-related cirrhosis or HCC. These findings indicate that the MICA rs2596542 has a significant role in HBV infection.