Quercetin nanocomposite as novel anticancer therapeutic: Improved efficiency and reduced toxicity

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• 作者：Giuseppe Cirillo ; Orazio Vittorio ; Silke Hampel ; Francesca Iemma ; Paolo Parchi ; Marco Cecchini ; Francesco Puoci ; Nevio Picci
• 关键词：Anticancer activity ; Carbon nanotubes ; Polymer therapeutics ; Free radical grafting
• 刊名：European Journal of Pharmaceutical Sciences
• 出版年：2013
• 出版时间：14 June, 2013
• 年：2013
• 卷：49
• 期：3
• 页码：359-365
• 全文大小：1468 K

文摘

A three-functional nanocomposite was prepared by radical polymerization of methacrylic acid around carbon nanotubes in the presence of Quercetin as biologically active molecule and proposed as new anticancer therapeutic. The so-obtained hybrid material was characterized by FT-IR, Raman, SEM, TEM analyses, while the functionalization degree of 2.33 mg of Quercetin per g of composite was assessed by Folin-Ciocalteu test. Antioxidant test (DPPH and ABTS) showed that the covalent coupling did not interfere with the antioxidant properties of the flavonoid, while the anticancer activity was greatly enhanced with a recorded IC₅₀ value much lower than free Quercetin. Cell viability tests on healthy cells demonstrated no-toxicity of the conjugate