Effects of valproate and carbamazepine on serum levels of homocysteine, vitamin B12, and folic acid

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• 作者：Karabiber ; Hamza ; Sonmezgoz ; Ergü ; n ; Ozerol ; Elif ; Yakinci ; Cengiz ; Otlu ; Baris ; Yologlu ; Saim
• 关键词：Homocysteine ; Sodium valproate ; Carbamazepine ; Folic acid ; Vitamin B12
• 刊名：Brain and Development
• 出版年：2003
• 出版时间：March, 2003
• 年：2003
• 卷：25
• 期：2
• 页码：113-115
• 全文大小：82.8 K

文摘

Homocysteine (HMC) is a sulfur containing amino acid, which plays a role in methionine metabolism. Folic acid (FA) and vitamin B12 (B12) are essential for remethylization of HMC to methionine. HMC level increases in the deficiency of these vitamins. Hyperhomocysteinemia causes vascular endothelial damage, which causes atherosclerosis. The aim of this study is to investigate the effect of valproate (VA) and carbamazepine (CBZ) on the serum levels of HMC, B12, and FA.