Utility of dynamic contrast-enhanced magnetic resonance imaging for differentiating glioblastoma, primary central nervous system lymphoma and brain metastatic tumor

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• 作者：Shanshan Lu ; MD PhD^a ; ^{lushan1118@163.com" class="auth_mail" title="E-mail the corresponding author} ; Qianqian Gao ; MS^a ; ^{gaoqian123011@163.com" class="auth_mail" title="E-mail the corresponding author} ; Jing Yu ; MD^a ; ^{yujing0303@163.com" class="auth_mail" title="E-mail the corresponding author} ; Yang Li ; MD^b ; ^{yuhao040511@163.com" class="auth_mail" title="E-mail the corresponding author} ; Peng Cao ; PhD^c ; ^{peng.cao@ge.com" class="auth_mail" title="E-mail the corresponding author} ; Haibin Shi ; MD PhD^a ; ^{hbshi346@163.com" class="auth_mail" title="E-mail the corresponding author} ; Xunning Hong ; MD^a ; ^{hongxunning@sina.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Glioblastoma ; Primary central nervous system lymphoma ; Metastasis ; Dynamic contrast-enhanced perfusion
• 刊名：European Journal of Radiology
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：85
• 期：10
• 页码：1722-1727
• 全文大小：1630 K

文摘

The study aimed to investigate the use of dynamic contrast-enhanced magnetic resonance imaging (MRI)-derived permeability parameters for the differentiation of glioblastoma multiformes (GBMs), primary central nervous system lymphomas (PCNSLs), and brain metastatic tumors (MTs).

Materials and methods

Seventy-five patients with histopathologically confirmed GBMs (n = 38), PCNSLs (n = 16) and MTs (n = 21) underwent dynamic contrast-enhanced MRIs before surgery. The volume transfer constant K^trans, the flux rate constant between extravascular extracellular space and plasma K_ep, the extravascular extracellular volume V_e and the fractional plasma volume V_p were measured within the entire contrast-enhancing tumor by extended Tofts model. A one-way analysis of variance was used to compare all of the parameters among these three tumors, followed by the post-hoc test. Receiver operating characteristic curves were constructed to evaluate the diagnostic performance of the permeability parameters.

Results

Mean K^trans value and V_e value were significantly higher in PCNSLs than in GBMs (P < 0.001 and P = 0.011) and MTs (P < 0.001 and P < 0.001). No significant difference was observed in all of the permeability parameters between GBMs and MTs. According to the receiver operating characteristic analyses, both K^trans and V_e had good diagnostic performance for discriminating between PCNSLs and GBMs (the area under the curve: 0.847 and 0.785, respectively), as well as between PCNSLs and MTs (the area under the curve: 0.851 and 0.884, respectively).

Conclusions

The K^trans and V_e derived from dynamic contrast-enhanced MRI facilitate the differentiation of PCNSLs from GBMs and MTs.