The effects of ibuprofen on sepsis parameters in preterm neonates

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• 作者：Gamze Demirel ; ^{kgamze@hotmail.com} ; Istemi Han Celik ; Fuat Emre Canpolat ; Omer Erdeve ; Serife Suna Oguz ; Ugur Dilmen
• 关键词：Ibuprofen ; Patent ductus arteriosus ; Preterm infants ; Sepsis ; C-reactive protein ; Interleukin-6
• 刊名：Early Human Development
• 出版年：2012
• 出版时间：April, 2012
• 年：2012
• 卷：88
• 期：4
• 页码：195-196
• 全文大小：126 K

文摘

Aim

To examine the effects of ibuprofen used for patent ductus arteriosus (PDA) treatment on the production of the proinflammatory cytokines C-reactive protein (CRP) and interleukin 6 (IL-6) in preterm septic newborns.

Methods

Patients with acute phase reactant elevation were divided into two groups according to receiving ibuprofen (Group I, n = 51) or not (Group II, n = 38). Course of sepsis was evaluated by CRP and IL-6 levels.

Results

CRP and IL-6 levels at the time of diagnosis were not different between two groups [16 ¡À 9.1 vs 16.4 ¡À 13.2 mg/dL (p = 0.43) for CRP and 124 ¡À 82 vs 119 ¡À 73 mg/dL (p = 0.517) for IL-6, respectively]. Similarly, they were statistically insignificant between the groups at the 2nd or 3rd days of ibuprofen treatment [14.3 ¡À 7.7 vs 13.7 ¡À 5.9 mg/dL (p = 0.21) for CRP and 83 ¡À 46 vs 86 ¡À 37 mg/dL (p = 0.29) for IL-6, respectively]. However, CRP and IL6 levels showed significant difference between groups in the following days; 6.03 ¡À 3.8 vs 9.1 ¡À 4.9 mg/dL (p = 0.025) for CRP and 42 ¡À 33.1 vs 58.9 ¡À 27.1 mg/dL (0.011) for IL-6 on 4th or 5th days of treatment and 2.3 ¡À 3.2 vs 4.1 ¡À 2.3 mg/dL (p = 0.032) for CRP and 16.1 ¡À 12.4 vs 21.3 ¡À 16.8 mg/dL (p = 0.016) for IL-6, on 7th to 10th days of treatment, respectively.

Conclusions

IL-6 and CRP may decrease in infants receiving ibuprofen treatment more than infants who do not receive it. This decrease should be considered at the time of caring a preterm infant with both sepsis and PDA after ibuprofen treatment.