Effect of the human therapeutic drug diltiazem on the haematological parameters, histology and selected enzymatic activities of rainbow trout Oncorhynchus mykiss
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- 作者：Christoph Steinbacha ; steinbach@frov.jcu.cz" class="auth_mail" title="E-mail the corresponding author ; Viktoriia Burkinaa ; Heike Schmidt-Posthausb ; Alzbeta Staraa ; Jitka Kolarovaa ; Josef Veliseka ; Tomas Randaka ; Hana Kocour Kroupovaa
- 关键词：Calcium channel blocker ; Creatine kinase ; Haematology ; Histopathological changes
- 刊名：Chemosphere
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：157
- 期：Complete
- 页码：57-64
- 全文大小：2458 K
文摘
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Diltiazem at concentrations of 3 and 30 μg L−1 affected the haematological and blood biochemical profile of rainbow trout.
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Creatine kinase activity was markedly increased at all tested diltiazem concentrations at the end of the exposure.
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Diltiazem exposed fish (30 μg L−1) showed scattered to mild histopathological changes in liver, kidney and heart.
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Antioxidant enzyme activity in liver and gills of trout at an environmentally relevant concentration was slightly affected.