Anesthetic effects on susceptibility to cortical spreading depression

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• 作者：Chiho Kudo ; ^{ckudo@dent.osaka-u.ac.jp} ; Midori Toyama ; Aiji Boku ; Hiroshi Hanamoto ; Yoshinari Morimoto ; Mitsutaka Sugimura ; Hitoshi Niwa
• 关键词：Cortical spreading depression ; Dexmedetomidine ; Isoflurane ; Neuronal injury ; Pentobarbital ; Propofol
• 刊名：Neuropharmacology
• 出版年：2013
• 出版时间：April, 2013
• 年：2013
• 卷：67
• 期：Complete
• 页码：32-36
• 全文大小：374 K

文摘

Cortical spreading depression (CSD) is a transient neuronal and glial depolarization and disruption of membrane ionic gradients that propagates slowly across the cerebral cortex. Recent clinical and experimental evidence has implicated CSD in the pathophysiology of migraines and neuronal injury states. In the current study, we examined the influence of four different anesthetics (propofol, dexmedetomidine, isoflurane, pentobarbital) on CSD susceptibility in a KCl application animal model. We found that isoflurane and dexmedetomidine suppressed CSD frequency, and tended to reduce the CSD propagation speed. Our data suggest that these anesthetics may be therapeutically beneficial in preventing CSD in diverse neuronal injury states.