In this paper the motivation and objectives for the creation of VARIwise are discussed, the structure of the software is outlined and an example of the use and utility of VARIwise is presented. Three irrigation control strategies have been simulated in VARIwise using a cotton model with a range of input parameters including spatially variable soil properties, non-uniform irrigation application, three weather profiles and two crop varieties. The simulated yield and water use efficiency were affected by the combination of input parameters and the control strategy implemented.