Regulation of Gene Expression through a Transcriptional Repressor that Senses Acyl-Chain Length in Membrane Phospholipids
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- 作者：Harald F. Hofbauer1 ; Florian H. Schopf1 ; Hannes Schleifer1 ; Oskar L. Knittelfelder1 ; Bartholomä ; us Pieber2 ; Gerald N. Rechberger1 ; 6 ; Heimo Wolinski1 ; 6 ; Maria L. Gaspar3 ; C. Oliver Kappe2 ; Johannes Stadlmann4 ; Karl Mechtler5 ; Alexandra Zenz1 ; Karl Lohner1 ; 6 ; Oksana Tehlivets1 ; 6 ; Susan A. Henry3 ; Sepp D. Kohlwein1 ; 6 ; sepp.kohlwein@uni-graz.at" class="auth_mail
- 刊名：Developmental Cell
- 出版年：23 June 2014
- 年：2014
- 卷：29
- 期：6
- 页码：729-739
- 全文大小：1943 K
文摘
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AMPK/Snf1 inhibition of acetyl-CoA carboxylase controls fatty acyl-chain length
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Opi1 repressor preferentially binds to C16 rather than C18 acyl-chains in PA
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Acyl-chain length tunes Opi1 sequestration to the ER and target gene derepression
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AMPK/Snf1 thus uses its effect on acyl-chain length to control Opi1 target genes