Optimization and pharmacological validation of a set-shifting procedure for assessing executive function in rats
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- 作者：R. Troudet1 ; E. Detrait2 ; E. Hanon ; Y. Lamberty ; yves.lamberty@ucb.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Set-shifting ; Prefrontal cortex ; Behavioral flexibility ; PCP ; Tolcapone ; Rat
- 刊名：Journal of Neuroscience Methods
- 出版年：2016
- 出版时间：1 August 2016
- 年：2016
- 卷：268
- 期：Complete
- 页码：182-188
- 全文大小：1105 K
文摘
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A widely used set-shifting protocol in a cross-maze was optimized for drug testing.
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The protocol was applied to rats treated by sub-chronic PCP administration.
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Potential reversal by tolcapone was also investigated.
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Overall, PCP-treated rats showed perseverative errors that could be reversed by tolcapone.