Two new nonacosanetriols from Ginkgo biloba sarcotesta

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• 作者：Guisheng Zhou^a ; Xin Yao^a ; Yuping Tang^a ; ^{yupingtang@njutcm.edu.cn} ; Nianyun Yang^a ; Hanqing Pang^a ; Xuan Mo^a ; Shaoqing Zhu^a ; Shulan Su^a ; Dawei Qian^a ; Chun Jin^b ; Yong Qin^b ; Jin-ao Duan^a ; ^{dja@njutcm.edu.cn}
• 关键词：ADP ; adenosine diphosphate ; COSY ; correlation spectroscopy ; DMAP ; 4-dimethylaminopyridine ; ESI ; electrospray ionization ; Gbs ; Ginkgo biloba sarcotesta ; HMBC ; heteronuclear multiple bond correlation ; HSQC ; heteronuclear singular quantum correlation ; HR ; hi
• 刊名：Chemistry and Physics of Lipids
• 出版年：2012
• 出版时间：October, 2012
• 年：2012
• 卷：165
• 期：7
• 页码：731-736
• 全文大小：389 K

文摘

Two new fatty alcohols named as (7S,8R,11S)-nonacosanetriol (1) and (10R,12R,15S)-nonacosanetriol (2), along with eight known compounds including ginkgolic acid (3), hydroginkgolic acid (4), sciadopitysin (5), ginkgetin (6), isoginkgetin (7), ginkgolide A (8), ginkgolide B (9) and ginkgolide C (10) have been isolated from the petroleum ether extract of Ginkgo biloba sarcotesta. Their structures were elucidated by means of chemical and extensive spectroscopic analysis. The absolute stereochemistry of compounds 1 and 2 was elucidated on the spectroscopic analysis of the R- and S-MTPA esters. Compounds 1 and 2 exhibited slight activity of antithrombin and moderate activity of antiplatelet aggregation in vitro. This was the first report regarding the anticoagulative activities of biflavonoids in G. biloba, and isoginkgetin (7) showed significant antithrombin and antiplatelet aggregation activity.