Downregulation of miR-199b promotes the acute spinal cord injury through IKKβ-NF-κB signaling pathway activating microglial cells
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- 作者：Heng-Jun Zhoua ; 1 ; Li-Qing Wangb ; 1 ; Qing-Sheng Xua ; 1 ; Zuo-Xu Fana ; Yu Zhua ; Hao Jianga ; Xiu-Jue Zhenga ; Yue-Hui Maa ; Ren-Ya Zhana ; zhanry148@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：MiR-199b ; Microglia ; Spinal cord injury ; IKKβ-NF-κB signaling pathway
- 刊名：Experimental Cell Research
- 出版年：2016
- 出版时间：15 November 2016
- 年：2016
- 卷：349
- 期：1
- 页码：60-67
- 全文大小：1438 K
文摘
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Downregulation of miR-199b and activation of IKKβ/NF-κB were observed in rat after SCI.
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miR-199b negatively regulated IKKβ by targeting its 3′-UTR.
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miR-199b overexpression reversed the increasing IKKβ, p-p65, TNF-α and IL-1β in LPS-treated BV2.
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BMS-345541 reversed the up-regulation of TNF-α and IL-1β induced by miR-199b inhibitor.
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Overexpression of miR-199b attenuated ASCI and decreased the expression of IKKβ-NF-κB in rats.