l-3-n-butylphthalide improves cognitive deficits in rats with chronic cerebral ischemia

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• 作者：Jing Xu^a ; Yiyi Wang^a ; ^b ; Ning Li^a ; Lanju Xu^c ; Hanyu Yang^c ; Zhuo Yang^a ; ^{zhuoyang@nankai.edu.cn}
• 关键词：3-n-Butylphthalide ; Hippocampus ; Ischemia ; MWM ; LTP
• 刊名：Neuropharmacology
• 出版年：2012
• 出版时间：June, 2012
• 年：2012
• 卷：62
• 期：7
• 页码：2424-2429
• 全文大小：1484 K

文摘

3-n-Butylphthalide (NBP) has been shown to have protective effects against ischemic stroke. In the present study, we investigated effects of l-3-n-butylphthalide (l-NBP) on the learning and memory impairment induced by chronic cerebral ischemia in rats. Male Wistar rats were administered 20?mg/kg l-NBP by gavage daily for 30 days after the bilateral common carotid artery clamping (two-vessel occlusion, 2-VO). Results showed that daily treatments of 20?mg/kg l-NBP significantly attenuated spatial learning deficits in Morris water maze (MWM) task. Results of long-term potentiation (LTP) indicated that treatment with 20?mg/kg l-NBP attenuated the inhibition of LTP in rat model of 2-VO. Moreover, l-NBP reduced glial fibrillary acidic protein (GFAP)-positive astrocytes induced by chronic cerebral ischemia. The present findings demonstrate the protective effect of l-NBP on chronic cerebral ischemia-induced hippocampus injury, which supports using l-NBP for therapy of cerebral ischemia in the future.