Rheb1-mTORC1 maintains macrophage differentiation and phagocytosis in mice
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- 作者：Xiaomin Wanga ; 1 ; Minghao Lia ; 1 ; Yanan Gaoa ; 1 ; Juan Gaoa ; Wanzhu Yanga ; Haoyue Lianga ; Qing Jia ; Yanxin Lia ; Hanzhi Liua ; Jian Huangb ; Tao Chenga ; Weiping Yuana ;
- 关键词：WBMCs ; whole bone marrow cells ; BM ; bone marrow ; PB ; peripheral blood ; FL ; fetal liver ; HSC ; hematopoietic stem cell ; GMP ; myeloid progenitor ; PC ; peritoneal cavity ; TG ; thioglycollate ; 3BDO ; 3-benzyl-5-((2-nitrophenoxy)methyl)&ndash ; dihydrofuran-2(3H)-one
- 刊名：Experimental Cell Research
- 出版年：2016
- 出版时间：10 June 2016
- 年：2016
- 卷：344
- 期：2
- 页码：219-228
- 全文大小：3506 K
文摘
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Rheb1 deletion impaired myeloid development in fetal liver and adult bone marrow.
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Rheb1 deletion inhibited the monocyte-to-macrophage differentiation process.
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Rheb1 deletion reduced phagocytosis of macrophages by decreasing mTORC1 activity.