Permethrin is a potential thyroid-disrupting chemical: In vivo and in silico envidence
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- 作者：Wenqing Tua ; b ; Chao Xub ; chaoxu@zjut.edu.cn" class="auth_mail" title="E-mail the corresponding author ; xuchao1212@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Yuanxiang Jinb ; Bin Lub ; Chunmian Linb ; Yongming Wua ; Weiping Liuc
- 关键词：CRH ; corticotropin-releasing hormone ; Dio ; deiodinase ; HPTaxis ; hypothalamic-pituitary-thyroid axis ; NIS ; sodium/iodide symporter ; NKX2.1 (TTF1) ; thyroid transcription factor-1 ; Pax8 ; paired box-8 ; PM ; permethrin ; SPs ; synthetic pyrethroids ; TG ; thyroglobulin ; THs ; thyroid hormones ; TPO ; thyroid peroxidase ; TRs ; thyroid receptors ; TSH ; thyroid-stimulating hormone ; TTR ; transthyretin ; UGT1ab ; uridine diphosphate glucuronosyltransferase
- 刊名：Aquatic Toxicology
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：175
- 期：Complete
- 页码：39-46
- 全文大小：1599 K
文摘
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Thyroid endocrine disruption in zebrafish embryos was investigated following exposure to permethrin (PM).
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PM exposure significantly increased the levels of thyroid hormones in embryos.
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Both in vivo and in silico studies clearly disclosed that PM potentially disrupts the thyroid endocrine system in fish.
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PM markedly accumulated in larvae with a preference for cis-PM.