Phenylboronic acid-functionalized polyamidoamine-mediated Bcl-2 siRNA delivery for inhibiting the cell proliferation
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- 作者：Di Wu1 ; Jiebing Yang1 ; Zhen Xing ; Haobo Han ; Tingting Wang ; Aijun Zhang ; Yan Yang ; yyan@jlu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Quanshun Li ; quanshun@jlu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Phenylboronic acid ; Polyamidoamine ; Bcl-2 ; siRNA delivery ; Multidrug resistance ; Cell proliferation
- 刊名：Colloids and Surfaces B: Biointerfaces
- 出版年：2016
- 出版时间：1 October 2016
- 年：2016
- 卷：146
- 期：Complete
- 页码：318-325
- 全文大小：2122 K
文摘
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Phenylboronic acid was conjugated to PAMAM to construct a derivative PPP.
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PPP could be used as a tumor-targeted carrier for Bcl-2 siRNA delivery.
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The transfection of Bcl-2 siRNA could inhibit the cell proliferation.