Comparison of counter-current chromatography and preparative high performance liquid chromatography applied to separating minor impurities in drug preparations
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- 作者：Shucai Li1 ; Wenwen Wang1 ; Huan Tang ; Kai Chen ; Jianhong Yang ; Linhong He ; Haoyu Ye ; Aihua Peng ; Lijuan Chen ; chenlijuan125@163.com" class="auth_mail
- 关键词：CCC ; Preparative HPLC ; Impurities ; Honokiol ; Quercetin
- 刊名：Journal of Chromatography A
- 出版年：30 May 2014
- 年：2014
- 卷：1344
- 期：Complete
- 页码：51-58
- 全文大小：1315 K
文摘
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Impurity separation of honokiol and quercetin by both preparative HPLC and CCC.
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Several performance parameters of separation were compared.
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CCC provided larger sample loading, especially for a sample with poor solubility.
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Six impurities of honokiol including one new compound were isolated.