A surface-grafted ligand functionalization strategy for coordinate binding of doxorubicin at surface of PEGylated mesoporous silica nanoparticles: Toward pH-responsive drug delivery
Iminodiacetic acid as a ligand was grafted on the vast surface of mesopores. Doxorubicin was loaded at surface of PEGylated mesoporous silica nanoparticles via coordinate binding. Enhanced drug loading, pH-responsive release and prolonged drug circulation time were achieved.