Systemic oxidative stress, as measured by urinary allantoin and F₂-isoprostanes, is not increased in Down syndrome

详细信息    查看全文

• 作者：Adviye A. Tolun ; MS ; PhD^a ; ¹ ; Peter M. Scarbrough ; PhD^b ; Haoyue Zhang ; PhD^a ; Jane-Ann McKillop ; MS^a ; Frances Wang ; MS^b ; Priya S. Kishnani ; MD^a ; David S. Millington ; PhD^a ; Sarah P. Young ; PhD^a ; Dora Il&rsquo ; yasova ; PhD^b ; ^{dora.ilyasova@duke.edu}
• 关键词：Down syndrome ; Biomarker ; Urine ; Tandem mass spectrometry
• 刊名：Annals of Epidemiology
• 出版年：2012
• 出版时间：December, 2012
• 年：2012
• 卷：22
• 期：12
• 页码：892-894
• 全文大小：113 K

文摘

Purpose

Oxidative stress has been implicated in Down syndrome (DS) pathology. This study compares DS individuals and controls on their urinary levels of allantoin and 2,3-dinor-iPF2¦Á-III; these biomarkers have been previously validated in a clinical model of oxidative stress.

Methods

Urine samples were collected from 48 individuals with DS and 130 controls. Biomarkers were assayed by ultraperformance liquid chromatography-tandem mass spectrometry, normalized by urinary creatinine concentration.

Results

After adjusting for age and gender, mean allantoin levels were lower among DS individuals versus controls (P?=?.04). The adjusted mean levels of 2,3-dinor-iPF2¦Á-III were similar in DS individuals and controls (P?=?.7).

Conclusions

Our results do not support the hypothesis that DS individuals have chronic systemic oxidative stress.