Urine samples were collected from 48 individuals with DS and 130 controls. Biomarkers were assayed by ultraperformance liquid chromatography-tandem mass spectrometry, normalized by urinary creatinine concentration.
After adjusting for age and gender, mean allantoin levels were lower among DS individuals versus controls (P?=?.04). The adjusted mean levels of 2,3-dinor-iPF2¦Á-III were similar in DS individuals and controls (P?=?.7).
Our results do not support the hypothesis that DS individuals have chronic systemic oxidative stress.