Antimicrobial resistance and molecular subtypes of Salmonella enterica serovar Typhi isolates from Kolkata, India over a 15 years period 1998-2012

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• 作者：Surojit Das^a ; Sriparna Samajpati^a ; Ujjwayini Ray^b ; Indranil Roy^c ; Shanta Dutta^a ; ^{shanta1232001@yahoo.co.in}
• 关键词：Salmonella Typhi ; Antimicrobial resistance ; IncHI1 plasmid ; Quinoloneresistance-determining region ; H58 haplotype ; Pulsed-field gel electrophoresis
• 刊名：International Journal of Medical Microbiology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：307
• 期：1
• 页码：28-36
• 全文大小：2032 K
• 卷排序：307

文摘

Multidrug-resistant S. Typhi declined with increase in nalidixic acid and ciprofloxacin resistance during 1998–2012. H58 haplotype was detected in majority of strains associated with either multidrug and/or fluoroquinolone resistance. Multidrug-resistant strains with or without plasmid shared the same set of resistance genes. Fluoroquinolone resistance was mediated by quinolone resistance-determining region mutation(s) in gyrA and parC genes. Pulsed-field gel electrophoresis showed more diversity among nalidixic acid-resistant strains than multidrug-resistant strains.