In Vivo Characterization of Linc-p21 Reveals Functional cis-Regulatory DNA Elements
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- 作者：Abigail F. Groff1 ; 2 ; 3 ; Diana B. Sanchez-Gomez1 ; Marcela M.L. Soruco1 ; 4 ; Chiara Gerhardinger1 ; A. Rasim Barutcu1 ; 3 ; Eric Li1 ; Lara Elcavage1 ; Olivia Plana1 ; Lluvia V. Sanchez1 ; James C. Lee1 ; 5 ; Martin Sauvageau1 ; 3 ; 4 ; John L. Rinn1 ; 3 ; 4 ; 6 ; john_rinn@harvard.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：23 August 2016
- 年：2016
- 卷：16
- 期：8
- 页码：2178-2186
- 全文大小：1404 K
文摘
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Linc-p21 regulates transcription of multiple local genes in vivo, including Cdkn1a
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Linc-p21 RNA is entirely dispensable for this cis-regulatory function
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Massively parallel reporter assay identifies several enhancer elements at this locus
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The Linc-p21 locus physically interacts with cis-regulated genes in human and mouse