Future directions in risk stratification and therapy for advanced pediatric genitourinary rhabdomyosarcoma
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- 作者：Miriam Harel ; M.D.a ; b ; MHarel@connecticutchildrens.org" class="auth_mail" title="E-mail the corresponding author ; Fernando A. Ferrer ; M.D.a ; b ; Linda H. Shapiro ; Ph.D.a ; b ; John H. Makari ; M.D.a ; b
- 关键词：Rhabdomyosarcoma ; Genitourinary ; Pediatric ; Risk stratification ; Multimodal therapy
- 刊名：Urologic Oncology: Seminars and Original Investigations
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：34
- 期：2
- 页码：103-115
- 全文大小：204 K
文摘
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We review advances in risk stratification and therapy for pediatric genitourinary RMS.
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Strategies for low-risk RMS aim to reduce toxicity and maintain favorable prognosis.
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Prognosis for high-risk disease remains poor, and novel treatments are needed.
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Advances in genetic analysis have led to refinement in risk stratification.
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Ongoing research holds promise for the development of novel targeted therapies.