Translational PET imaging research

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• 作者：Richard J. Hargreaves ; Eugenii A. Rabiner
• 关键词：Positron emission tomography (PET) imaging ; Drug development ; Target engagement imaging ; Psychiatry imaging
• 刊名：Neurobiology of Disease
• 出版年：January, 2014
• 年：2014
• 卷：61
• 期：Complete
• 页码：32-38
• 全文大小：565 K

文摘

The goal of any early central nervous system (CNS) drug development program is always to test the mechanism and not the molecule in order to support additional research investments in late phase clinical trials. Confirmation that drugs reach their targets using translational positron emission tomography (PET) imaging markers of engagement is central to successful clinical proof-of-concept testing and has become an important feature of most neuropsychiatric drug development programs. CNS PET imaging can also play an important role in the clinical investigation of the neuropharmacological basis of psychiatric disease and the optimization of drug therapy.