- 作者：Valerie Voon ; Michael A. Irvine ; Katherine Derbyshire ; Yulia Worbe ; Iris Lange ; Sanja Abbott ; Sharon Morein-Zamir ; Robyn Dudley ; Daniele Caprioli ; Neil A. Harrison ; Jonathan Wood ; Jeffrey W. Dalley ; Edward T. Bullmore ; Jon E. Grant ; Trevor W. Robbins
- 关键词：Binge eating ; impulsivity ; motivation ; obesity ; premature responding ; substance use disorders
- 刊名：Biological Psychiatry
- 出版年：15 January, 2014
- 年：2014
- 卷：75
- 期：2
- 页码：148-155
- 全文大小：421 K
Background
Premature responding is a form of motor impulsivity that preclinical evidence has shown to predict compulsive drug seeking but has not yet been studied in humans. We developed a novel translation of the task, based on the rodent 5-choice serial reaction time task, testing premature responding in disorders of drug and natural food rewards.Methods
Abstinent alcohol- (n = 30) and methamphetamine-dependent (n = 23) subjects, recreational cannabis users (n = 30), and obese subjects with (n = 30) and without (n = 30) binge eating disorder (BED) were compared with matched healthy volunteers and tested on the premature responding task.
Results
Compared with healthy volunteers, alcohol- and methamphetamine-dependent subjects and cannabis users showed greater premature responding with no differences observed in obese subjects with or without BED. Current smokers exhibited greater premature responding versus ex-smokers and nonsmokers. Alcohol-dependent subjects also had lower motivation for explicit monetary incentives. A Motivation Index correlated negatively with alcohol use and binge eating severity.
Conclusions
Premature responding on a novel translation of a serial reaction time task was more evident in substance use disorders but not in obese subjects with or without BED. Lower motivation for monetary incentives linked alcohol use and binge eating severity. Our findings add to understanding the relationship between drug and natural food rewards.