Clinical meaningfulness of complete skin clearance in psoriasis

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• 作者：Bruce Strober ; MD ; PhD^a ; ^{strober@uchc.edu" class="auth_mail" title="E-mail the corresponding author} ; Kim A. Papp ; MD ; PhD^b ; ^c ; Mark Lebwohl ; MD^d ; Kristian Reich ; MD^e ; Carle Paul ; MD ; PhD^f ; Andrew Blauvelt ; MD^g ; Kenneth B. Gordon ; MD^h ; Cassandra E. Milmont ; PhDⁱ ; Hema N. Viswanathan ; PhDⁱ ; Joanne Li ; PhDⁱ ; Lionel Pinto ; PhDⁱ ; David J. Harrison ; PhDⁱ ; Greg Kricorian ; MDⁱ ; Ajay Nirula ; MD ; PhDⁱ ; Paul Klekotka ; MD ; PhDⁱ
• 关键词：Dermatology Life Quality Index ; health-related quality of life ; patient-reported outcomes ; plaque psoriasis ; Psoriasis Area and Severity Index ; Psoriasis Symptom Inventory ; static Physician Global Assessment
• 刊名：Journal of the American Academy of Dermatology
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：75
• 期：1
• 页码：77-82.e7
• 全文大小：261 K

文摘

New psoriasis therapies have increased the ability to achieve skin clearance. However, insufficient evidence exists on the impact of total skin clearance from the patient perspective.

Objective

We sought to determine if complete skin clearance is clinically meaningful compared with treatment responses without clearance.

Methods

Pooled data from 3 phase-III trials were used to compare results for patients with complete skin clearance (Psoriasis Area and Severity Index [PASI] 100 or static Physician Global Assessment score 0) with patients without complete skin clearance (PASI 75 to <100 or static Physician Global Assessment score 1) based on Psoriasis Symptom Inventory and Dermatology Life Quality Index.

Results

Percentages of patients with Psoriasis Symptom Inventory score 0 were 45% for those achieving PASI 100 and 8% for PASI 75 to <100 (m>Pm> < .001). Respective percentages with Dermatology Life Quality Index score 0/1 were 80% and 55% (m>Pm> < .001). PASI 100 resulted in incremental improvement over PASI 90 to <100 (incremental differences of 28% for Psoriasis Symptom Inventory score 0 and 18% for Dermatology Life Quality Index score 0). Similar results were observed for static Physician Global Assessment scores 0 versus 1.

Conclusions

Complete skin clearance represents a clinically meaningful end point and outcome for patients, reflected in experiences of no psoriasis symptoms and no impairment on health-related quality of life.