Decrypting the genome's alternative messages

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• 作者：Britta Hartmann ; Juan Valcá ; rcel
• 刊名：Current Opinion in Cell Biology
• 出版年：2009
• 出版时间：June 2009
• 年：2009
• 卷：21
• 期：3
• 页码：377-386
• 全文大小：513 K

文摘

Alternative splicing of messenger RNA (mRNA) precursors affects the majority of human genes, has a considerable impact on eukaryotic gene function and offers distinct opportunities for regulation. Alterations in alternative splicing can cause or modify the progression of a significant number of pathologies. Recent high-throughput technologies have uncovered a wealth of transcript diversity generated by alternative splicing, as well as examples for how this diversity can be established and become misregulated. A variety of mechanisms modulate splice site choice coordinately with other cellular processes, from transcription and mRNA editing or decay to miRNA-based regulation and telomerase function. Alternative splicing studies can contribute to our understanding of multiple biological processes, including genetic diversity, speciation, cell/stem cell differentiation, nervous system function, neuromuscular disorders and tumour progression.