Incidence of persistent viraemia and latent feline leukaemia virus infection in cats with lymphoma

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• 作者：Bianca Stü ; tzer Dr Med Vet¹ ; Karin Simon Dr Med Vet¹ ; Hans Lutz Dr Med Vet ; Prof² ; Monir Majzoub Dr Med Vet³ ; Walter Hermanns Dr Med Vet ; Prof ; Dipl ECVP³ ; Johannes Hirschberger Dr Med Vet ; Prof ; Dipl ECVIM-CA (Internal Medicine) ; Dipl ECVIM-CA (Oncology)¹ ; Carola Sauter-Louis Dr Med Vet⁴ ; Katrin Hartmann Dr Med Vet ; Prof ; Dipl ECVIM-CA (Internal Medicine)¹ ; ^{hartmann@lmu.de}
• 刊名：Journal of Feline Medicine Surgery
• 出版年：2011
• 出版时间：February 2011
• 年：2011
• 卷：13
• 期：2
• 页码：81-87
• 全文大小：165 K

文摘

In the past, feline leukaemia virus (FeLV) infection, and also latent FeLV infection, were commonly associated with lymphoma and leukaemia. In this study, the prevalence of FeLV provirus in tumour tissue and bone marrow in FeLV antigen-negative cats with these tumours was assessed. Seventy-seven diseased cats were surveyed (61 antigen-negative, 16 antigen-positive). Blood, bone marrow, and tumour samples were investigated by two polymerase chain reaction (PCR) assays detecting deoxyribonucleic acid (DNA) sequences of the long terminal repeats (LTR) and the envelope (env) region of the FeLV genome. Immunohistochemistry (IHC) was performed in bone marrow and tumour tissue. None of the antigen-negative cats with lymphoma was detectably infected with latent FeLV. The prevalence of FeLV viraemia in cats with lymphoma was 20.8 % . This suggests that causes other than FeLV play a role in tumourgenesis, and that latent FeLV infection is unlikely to be responsible for most feline lymphomas and leukaemias.