Affective reactivity in heroin-dependent patients with antisocial personality disorder

详细信息    查看全文

• 作者：Marc Walter^a ; ^{marc.walter@upkbs.ch} ; Bigna Degen^a ; ^b ; Constanze Treugut^a ; J&#xfc ; rgen Albrich^a ; ^b ; Monika Oppel^a ; ^b ; André ; Schulz^c ; Hartmut Schä ; chinger^b ; ^c ; Kenneth M. D&#xfc ; rsteler-MacFarland^a ; ^d ; Gerhard A. Wiesbeck^a
• 关键词：Addiction ; Antisocial personality disorder ; Heroin ; Opioid maintenance treatment ; Startle reflex
• 刊名：Psychiatry Research
• 出版年：2011
• 出版时间：15 May 2011
• 年：2011
• 卷：187
• 期：1-2
• 页码：210-213
• 全文大小：241 K

文摘

The Antisocial personality disorder (ASPD), one of the most common co-morbid psychiatric disorders in heroin-dependent patients, is associated with a lack of affective modulation. The present study aimed to compare the affect-modulated startle responses of opioid-maintained heroin-dependent patients with and without ASPD relative to those of healthy controls. Sixty participants (20 heroin-dependent patients with ASPD, 20 heroin-dependent patients without ASPD, 20 healthy controls) were investigated in an affect-modulated startle experiment. Participants viewed neutral, pleasant, unpleasant, and drug-related stimuli while eye-blink responses to randomly delivered startling noises were recorded continuously. Both groups of heroin-dependent patients exhibited significantly smaller startle responses (raw values) than healthy controls. However, they showed a normal affective modulation: higher startle responses to unpleasant, lower startle responses to pleasant stimuli and no difference to drug-related stimuli compared to neutral stimuli. These findings indicate a normally modulated affective reactivity in heroin-dependent patients with ASPD.