Synthesis of biotinylated photoaffinity probes based on arylsulfonamide γ-secretase inhibitors
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- 作者：Haruhiko Fuwa ; Kenichi Hiromoto ; Yasuko Takahashi ; Satoshi Yokoshima ; Toshiyuki Kan ; Tohru Fukuyama ; Takeshi Iwatsubo ; Taisuke Tomita and Hideaki Natsugari
- 关键词：Structure– ; activity relationships ; Photoaffinity probes ; Arylsulfonamides ; γ ; -Secretase inhibitors
- 刊名：Bioorganic and Medicinal Chemistry Letters
- 出版年：2006
- 出版时间：15 August 2006
- 年：2006
- 卷：16
- 期：16
- 页码：4184-4189
- 全文大小：150 K
文摘
Synthesis and biological evaluation of an arylsulfonamide class of γ-secretase inhibitors are described. Design, synthesis, and biological evaluation of multifunctional molecular probes harboring a benzophenone photophore as a cross-linking group and a biotin tag are also reported.