Synthetic studies on goniodomin A: convergent assembly of the C15–C36 segment via palladium-catalyzed organostannane–thioester coupling

详细信息    查看全文

• 作者：Tomoyuki Saito ; Haruhiko Fuwa ; Makoto Sasaki
• 刊名：Tetrahedron
• 出版年：2011
• 出版时间：14 January 2011
• 年：2011
• 卷：67
• 期：2
• 页码：429-445
• 全文大小：1192 K

文摘

A stereocontrolled convergent synthesis of the C15–C36 segment of goniodomin A, a potent anti-angiogenic marine polyether macrolide, has been achieved using Stille-type cross-coupling reaction of a vinylstannane and a thioester as a key segment assembly process.