Fibroblast growth factor 21 has no direct role in regulating fertility in female mice
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- 作者：Garima Singhal1 ; Nicholas Douris1 ; 3 ; Alan J. Fish1 ; Xinyao Zhang1 ; Andrew C. Adams2 ; Jeffrey S. Flier1 ; Pavlos Pissios1 ; ppissios@bidmc.harvard.edu" class="auth_mail" title="E-mail the corresponding author ; Eleftheria Maratos-Flier1 ; emaratos@bidmc.harvard.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：FGF21 ; Fertility ; Leptin ; Hypothalamic action
- 刊名：Molecular Metabolism
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：5
- 期：8
- 页码：690-698
- 全文大小：961 K
文摘
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Ketogenic diet fed mice remain fertile despite significant elevation in serum FGF21.
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Central infusion of FGF21 does not suppress fertility in female mice.
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Mice lacking FGF21 have similar post-fasting delay of cycling as control mice.
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High fat diet restores fertility in FGF21-Tg mice despite supra physiological serum FGF21.