Dietary flavonoid intake and Barrett's esophagus in western Washington State

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• 作者：Jessica L. Petrick ; PhD ; MPH^a ; ^{jessica.petrick@unc.edu" class="auth_mail" title="E-mail the corresponding author} ; Susan E. Steck ; PhD ; MPH ; RD^b ; Patrick T. Bradshaw ; PhD ; MS^c ; Wong-Ho Chow ; PhD^d ; Lawrence S. Engel ; PhD ; MS^a ; Ka He ; ScD ; MD ; MPH^e ; Harvey A. Risch ; MD ; PhD^f ; Thomas L. Vaughan ; MD ; MPH^g ; Marilie D. Gammon ; PhD^a
• 关键词：Barrett's esophagus ; Diet ; Epidemiologic studies ; Flavonoids
• 刊名：Annals of Epidemiology
• 出版年：2015
• 出版时间：October 2015
• 年：2015
• 卷：25
• 期：10
• 页码：730-735.e2
• 全文大小：300 K

文摘

Flavonoids, concentrated in fruits and vegetables, demonstrate in experimental studies chemopreventive properties in relation to Barrett's esophagus (BE), a precursor lesion for esophageal adenocarcinoma. One case-control investigation reported an inverse association between isoflavone intake and odds of BE, yet no epidemiologic study has considered other flavonoid classes, which are more commonly consumed by Americans.

Methods

We examined intake of total flavonoids, six flavonoid classes, and lignans among case-control study participants in western Washington State. Food frequency questionnaires were self-completed by BE cases with specialized intestinal metaplasia (n = 170) and matched controls (n = 183).

Results

In logistic regression models adjusted for age, sex, body mass index, and energy intake, the odds ratio (OR) for specialized intestinal metaplasia BE associated with anthocyanidin intake was 0.49 (95% confidence interval: 0.30–0.80, for quartiles 2–4 combined vs. quartile 1), for which wine and fruit juice were major dietary sources. More moderate decreased ORs were noted for flavanones, flavonols, isoflavones, and lignans. A modest increased OR was observed for flavones, for which pizza was the main dietary source in our population.

Conclusions

Our findings of an inverse association between anthocyanidins and odds of BE suggest that adequate dietary intake of these compounds may lower risk of this cancer precursor lesion.