The clinicopathological and prognostic significance of CD24, CD44, CD133, ALDH1 expressions in invasive ductal carcinoma of the breast: CD44/CD24 expression in breast cancer

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• 作者：Nilgü ; n Kapucuo臒lu^a ; ^{nilgunkap@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; Kemal Kü ; r艧at Bozkurt^a ; ^{kemalkbozkurt@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; 艦irin Ba艧p谋nar^a ; ^{sirinbaspinar@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Murat Koç ; er^b ; ^{muratkocer71@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; Hasan Erol Ero臒lu^c ; ^{eroglue@med.sdu.edu.tr" class="auth_mail" title="E-mail the corresponding author} ; Ra艧it Akdeniz^a ; ^{rasit.akdeniz@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; Mehtap Akç ; il^d ; ^{matemel@baskent.edu.tr" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Cancer stem cell ; Breast cancer ; CD44/CD24 ; ALDH1 ; CD133
• 刊名：Pathology - Research and Practice
• 出版年：2015
• 出版时间：October 2015
• 年：2015
• 卷：211
• 期：10
• 页码：740-747
• 全文大小：4152 K

文摘

Recently, there are several studies about cancer stem cells (CSC), indicating that they are the cells that initiate the tumor, provide progression, metastasis and responsible for the aggressive tumor behavior.

bsSec_2">Materials and methods

The purpose of this study is to investigate the expressions of CD24, CD44, their different combinations, ALDH1 and CD133 in invasive ductal carcinoma. Their relationships with clinicopathologic parameters, such as tumor grade, lymphovascular invasion, tumor size, axillary lymph node involvement, stage, hormone receptors, HER2 expression, basal like tumors, triple negative status and prognosis were also investigated. Tissue microarray method was used to investigate 谋mmunohistochemical CD24, CD44, ALDH1 and CD133 expressions in 105 invasive ductal carcinoma cases.

bsSec_3">Results

CD133 expression was significantly associated with tumor size (p = 0.023) and stage (p = 0.009). CD133 expression was decreased in tumors with larger tumor size, higher stage and lymphovascular invasion. CD133 expression was positively correlated with CD44 (r = 0.212, p = 0.032) and CD44⁺/CD24⁺ (r = 0.202, p = 0.040) expressions. CD44, CD24 and ALDH1 expressions showed no significant relationship and correlation with clinicopathologic features. There was a significant relationship (p = 0.048) between CD44⁺/CD24^−/low phenotype and basal like tumors. EGFR expression was positively correlated with CD44⁺/CD24^−/low phenotype (r = 0.211, p = 0.036).

bsSec_4">Conclusions

Basal like tumors are enriched for CSCs with CD44⁺/CD24^−/low phenotype. CD133 can detect a different population of CSC in breast carcinoma.