- 作者：Hyohun Park ; Goji Hasegawa ; Toshihide Shima ; Michiaki Fukui ; Naoto Nakamura ; Kanji Yamaguchi ; Hironori Mitsuyoshi ; Masahito Minami ; Kohichiroh Yasui ; Yoshito Itoh ; Toshikazu Yoshikawa ; Jo Kitawaki ; Mi
- 关键词：Fatty acid component ; Nonalcoholic fatty liver disease ; Insulin resistance ; Ezetimibe ; Metabolic syndrome ; Lipid metabolism
- 刊名：Clinica Chimica Acta
- 出版年：2010
- 出版时间：11 November 2010
- 年：2010
- 卷：411
- 期：21-22
- 页码：1735-1740
- 全文大小：197 K
BackgroundThe aim of this study was to investigate the relationship between fatty acid composition of plasma cholesteryl esters (CEs) and estimated desaturase activity and the development and progression of nonalcoholic fatty liver disease (NAFLD). The study also assessed the effect of ezetimibe on CE levels.Methods
Plasma CEs fatty acid composition was analyzed in 3 groups: patients with a NAFLD activity score (NAS) ≤ 4 (n = 31) or NAS ≥ 5 (n = 32) and normal controls (n = 25). The estimated desaturase activities were calculated using ratios of 16:1n−7/16:0 (D9-16D), 18:1n−9/18:0 (D9-18D), 18:3n−6/18:2n−6 (D6D) and 20:4n−6/20:3n−6 (D5D).
Results
Compared with controls, the levels of palmitate, palmitoleate, γ-linoleate, D9-16D and D6D were significantly increased, whereas levels of linoleate and D5D were significantly decreased. Patients with NAS ≥ 5 had significantly higher palmitate levels than patients with NAS ≤ 4. The levels of these fatty acids, especially palmitate and palmitoleate, correlated with NAFLD-related lipid, metabolic, and inflammatory parameters. Long-term therapy with ezetimibe caused significant improvements in the levels of these fatty acids, estimated desaturase activity index and NAFLD-related parameters.
Conclusions
Our results suggest that fatty acids and desaturase activity associate with the development and progression of NAFLD, and that ezetimibe may be a novel treatment for this disorder.