- 作者：Hiroshi Okada ; Michiaki Fukui ; Muhei Tanaka ; Shinobu Matsumoto ; Kanae Kobayashi ; Hiroya Iwase ; Kiichiro Tomiyasu ; Koji Nakano ; Goji Hasegawa ; Naoto Nakamura
- 关键词：CVD ; cardio vascular disease ; UAE ; urinary albumin excretion ; BMI ; body mass index ; ACE ; angiotensin-converting enzyme ; ARB ; angiotensin II receptor blockers ; ANOVA ; analysis of variance ; SBP ; systolic blood pressure ; CI ; confidence interval ; CCB ; calcium-channel blockers ; LDL ; low-density lipoprotein ; VCAM-1 ; vascular cell adhesion molecule 1 ; ICAM-1 ; intercellular adhesion molecule 1
- 刊名：Metabolism
- 出版年：March, 2014
- 年：2014
- 卷：63
- 期：3
- 页码：409-414
- 全文大小：287 K
Objective
Bilirubin has been recognized as an important endogeneous antioxidant. Previous studies reported that bilirubin could prevent atherosclerosis. The aim of this study was to investigate if serum bilirubin concentration could be a predictor for the development of albuminuria in patients with type 2 diabetes.Materials and Methods
We measured serum bilirubin in 320 consecutive patients with normoalbuminuria. We performed follow-up study to assess the development of albuminuria, mean interval of which was 3.2 卤 0.9 years. Cox proportional hazards regression was used to examine the relationship between serum bilirubin concentration and the development of albuminuria.
Results
During follow-up duration, 43 patients have developed albuminuria. In multivariate analysis, after adjusting for comprehensive risk factors, the risk of developing albuminuria was higher in the lowest quartile of serum bilirubin concentrations than that in the highest quartile of serum bilirubin concentrations (Hazard ratio, 5.76; 95% CI, 1.65 to 24.93).
Conclusions
Low serum bilirubin concentration could be a novel risk factor for the development of albuminuria in patients with type 2 diabetes.