Computationally Designed Bispecific Antibodies using Negative State Repertoires
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- 作者：Andrew Leaver-Fay
- 刊名：Structure
- 出版年：2016
- 出版时间：5 April 2016
- 年：2016
- 卷：24
- 期：4
- 页码：641-651
- 全文大小：3184 K
文摘
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- <p id="p0010">Protein specificity design improves with the use of repertoires of negative statesp>
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- <p id="p0015">This article presents several novel CH3 heterodimers resulting from multistate designp>
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- <p id="p0020">A novel xtal technique revealed the heterodimeric interfaces, otherwise unresolvedp>
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- <p id="p0025">LCMS showed two CH3 interfaces averaging 93% purity for four bispecific antibodiesp>