Leishmania exosomes and other virulence factors: Impact on innate immune response and macrophage functions

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• 作者：Vanessa Diniz Atayde¹ ; Kasra Hassani¹ ; Alonso da Silva Lira Filho ; Andrezza Raposo Borges ; Anupam Adhikari ; Caroline Martel ; Martin Olivier ; ^{martin.olivier@mcgill.ca}
• 关键词：Leishmania ; Exosome ; GP63 ; Immune response
• 刊名：Cellular Immunology
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：309
• 期：Complete
• 页码：7-18
• 全文大小：532 K
• 卷排序：309

文摘

Leishmania is able to render the host macrophage inactive and persist inside its phagolysosome by employing immune modulatory mechanisms. Leishmania exosomes are pro-inflammatory to the host, exacerbating the pathology. Herein we provide the most recent insights on the role of exosomes and other virulence factors, especially the surface protease GP63, in Leishmania-host interactions.