The structural and functional effects of Hg(II) and Cd(II) on lipid model systems and human erythrocytes: A review
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- 作者：Brandon J. Payliss ; Mohamed Hassanin ; Elmar J. Prenner ; eprenner@ucalgary.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：SM ; sphingomyelin ; PC ; phosphatidylcholine ; PE ; phosphatidylethanolamine ; (PS) ; phosphatidylserine ; PG ; phosphatidylglycerol ; PA ; phosphatidic acid ; POPC ; 1-palmitoyl-2-oleoyl-sn-phosphatidylcholine ; POPE ; 1-palmitoyl-2-oleoyl-sn-phosphatidylethanolamine ; POPS ; 1-palmitoyl-2-oleoyl-sn-phosphatidylserine ; DMPC ; dimyristoylphosphatidylcholine ; DMPE ; dimyristoylphosphatidylethanolamine ; DMPS ; dimyristoylphosphatidylserine ; DMPA ; dimyristoylphosphatidic acid ; DMPG ; dimyristoylphosphatidyl ; DOPC ; dio
- 刊名：Chemistry and Physics of Lipids
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：193
- 期：Complete
- 页码：36-51
- 全文大小：1101 K
文摘
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The chemical speciation of mercury and cadmium in aqueous solution plays a key role in metal-membrane interactions.
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The interactions of mercury and cadmium with lipid model membranes depend on all elements of lipid structure.
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Diverse methodologies, experimental conditions, and a variety of lipid model systems explain variable results between studies.
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At physiological conditions, Cd prefers binding to PE in contrast to mercury which rather targets PS
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A more standardized set of experimental procedures would allow better comparison between various studies.