A rapid, one-pot, four-component route to 2H-indazolo[2,1-b]phthalazine-triones

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• 作者：Elaheh Mosaddegh^a ; ^b ; ^{mosaddegh_e@yahoo.com} ; ^{emosaddegh@gmail.com} ; Asadollah Hassankhani^c
• 刊名：Tetrahedron Letters
• 出版年：2011
• 出版时间：26 January 2011
• 年：2011
• 卷：52
• 期：4
• 页码：488-490
• 全文大小：188 K

文摘

A new, efficient, and environmentally benign protocol for the one-pot, four-component synthesis of 2,2-dimethyl-13-phenyl-2,3-dihydro-1H-indazolo[2,1-b]phthalazine-1,6,11(13H)-trione by condensation of phthalic anhydride, hydrazinium hydroxide, aromatic aldehydes, and dimedone catalyzed by Ce(SO₄)₂·4H₂O as an ecofriendly catalyst with high catalytic activity and reusability at 125 °C under solvent-free conditions is reported. The reaction proceeds to completion within 5–10 min in 71–95 % yield. To the best of our knowledge, this new procedure provides the first example of an efficient synthetic method for 2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-trione via a four-component reaction.