¹¹C-methionine uptake correlates with tumor cell density rather than with microvessel density in glioma: A stereotactic image-histology comparison

详细信息    查看全文

• 作者：Yoshiko Okita ; Manabu Kinoshita ; Tetsu Goto ; Naoki Kagawa ; Haruhiko Kishima ; Eku Shimosegawa ; Jun Hatazawa ; Naoya Hashimoto ; Toshiki Yoshimine
• 关键词：¹¹C-methionine positron emission tomography (¹¹C-methionine PET) ; Tumor cell density ; Proliferation ; Microvessel density ; Angiogenesis ; Glioma
• 刊名：NeuroImage
• 出版年：2010
• 出版时间：15 February 2010
• 年：2010
• 卷：49
• 期：4
• 页码：2977-2982
• 全文大小：678 K

文摘

¹¹C-methionine positron emission tomography (¹¹C-methionine PET) provides accurate detection of brain tumors. Several reports have analyzed the correlation between uptake of ¹¹C-methionine and Ki-67 index or microvessel density non-stereotactically and suggested that ¹¹C-methionine uptake reflects both proliferation potential and angiogenic capability in gliomas. As gliomas possess heterogeneous histological architecture, non-stereotactic comparison of the histology and ¹¹C-methionine PET image may not be accurate. In the present study, the correlation between ¹¹C-methionine uptake and cell or microvessel density was analyzed using histological specimens obtained by stereotactic biopsy, and an exact local comparison of ¹¹C-methionine PET image and histological specimens was conducted. The tumor/normal tissue (T/N) ratio of ¹¹C-methionine positron emission tomography was found to correlate better with cell density (R = 0.747, p = 0.000042) and Ki-67 index (R = 0.675, p = 0.00041) than with microvessel density (R = 0.467, p = 0.025) in a histological comparison using a stereotactic image. Furthermore, multiple linear regression analysis revealed that cell density was the key determinant for predicting ¹¹C-methionine level while microvessel density was not. These results suggest that cell density contributes more to ¹¹C-methionine uptake than microvessel density in glioma tissues and that the previously reported correlation of ¹¹C-methionine uptake and microvessel density in glioma patients requires reevaluation.