Genome-wide association study confirms lung cancer susceptibility loci on chromosomes 5p15 and 15q25 in an African-American population
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- 作者：Krista A. Zanettia ; 1 ; zanettik@mail.nih.gov" class="auth_mail" title="E-mail the corresponding author ; Zhaoming Wangb ; 1 ; wangzha@mail.nih.gov" class="auth_mail" title="E-mail the corresponding author ; Melinda Aldrichc ; d ; melinda.aldrich@Vanderbilt.Edu" class="auth_mail" title="E-mail the corresponding author ; Christopher I. Amose ; Christopher.I.Amos@Dartmouth.edu" class="auth_mail" title="E-mail the corresponding author ; William J. Blotc ; blotw@iei.us" class="auth_mail" title="E-mail the corresponding author ; Elise D. Bowmanf ; bowmane@intra.nci.nih.gov" class="auth_mail" title="E-mail the corresponding author ; Laurie Burdetteb ; burdettl@mail.nih.gov" class="auth_mail" title="E-mail the corresponding author ; Qiuyin Caic ; qiuyin.cai@Vanderbilt.Edu" class="auth_mail" title="E-mail the corresponding author ; Neil Caporasob ; caporasn@mail.nih.gov" class="auth_mail" title="E-mail the corresponding author ; Charles C. Chungb ; chungcc@mail.nih.gov" class="auth_mail" title="E-mail the corresponding author ; Elizabeth M. Gillandersa ; lgilland@mail.nih.gov" class="auth_mail" title="E-mail the corresponding author ; Christopher A. Haimang ; haiman@usc.edu" class="auth_mail" title="E-mail the corresponding author ; Helen M. Hansenh ; helen.hansen@ucsf.edu" class="auth_mail" title="E-mail the corresponding author ; Brian E. Hendersong ; Laurence N. Koloneli ; lkolonel@cc.hawaii.edu" class="auth_mail" title="E-mail the corresponding author ; Loic Le Marchandi ; Loic@cc.hawaii.edu" class="auth_mail" title="E-mail the corresponding author ; Shengchao Lib ; shengchao.li@nih.gov" class="auth_mail" title="E-mail the corresponding author ; Lorna Haughton McNeillj ; lmcneill@mdanderson.org" class="auth_mail" title="E-mail the corresponding author ; Brí ; d M. Ryanf ; ryanb@mail.nih.gov" class="auth_mail" title="E-mail the corresponding author ; Ann G. Schwartzk ; schwarta@karmanos.org" class="auth_mail" title="E-mail the corresponding author ; Jennette D. Sisonh ; jennette.sison@ucsf.edu" class="auth_mail" title="E-mail the corresponding author ; Margaret R. Spitzl ; spitz@bcm.edu" class="auth_mail" title="E-mail the corresponding author ; Margaret Tuckerb ; tuckerp@mail.nih.gov" class="auth_mail" title="E-mail the corresponding author ; Angela S. Wenzlaffk ; wenzlaff@karmanos.org" class="auth_mail" title="E-mail the corresponding author ; John K. Wienckeh ; john.wiencke@ucsf.edu" class="auth_mail" title="E-mail the corresponding author ; Lynne Wilkensi ; lynne@cc.hawaii.edu" class="auth_mail" title="E-mail the corresponding author ; Margaret R. Wrenschh ; Margaret.Wrensch@ucsf.edu" class="auth_mail" title="E-mail the corresponding author ; Xifeng Wum ; xwu@mdanderson.org" class="auth_mail" title="E-mail the corresponding author ; Wei Zhengc ; wei.zheng@vanderbilt.edu" class="auth_mail" title="E-mail the corresponding author ; Weiyin Zhoub ; zhouw@mail.nih.gov" class="auth_mail" title="E-mail the corresponding author ; David Christianin ; dchris@hsph.harvard.edu" class="auth_mail" title="E-mail the corresponding author ; Julie R. Palmero ; jpalmer@bu.edu" class="auth_mail" title="E-mail the corresponding author ; Trevor M. Penningp ; q ; PENNING@UPENN.EDU" class="auth_mail" title="E-mail the corresponding author ; Alyssa G. Rieberr ; arieber@mdanderson.org" class="auth_mail" title="E-mail the corresponding author ; Lynn Rosenbergo ; lrosenbe@bu.edu" class="auth_mail" title="E-mail the corresponding author ; Edward A. Ruiz-Narvaezo ; eruiznar@bu.edu" class="auth_mail" title="E-mail the corresponding author ; Li Sun ; lisu@hsph.harvard.edu" class="auth_mail" title="E-mail the corresponding author ; Anil Vachanip ; s ; avachani@mail.med.upenn.edu" class="auth_mail" title="E-mail the corresponding author ; Yongyue Wein ; ywei@hsph.harvard.edu" class="auth_mail" title="E-mail the corresponding author ; Alexander S. Whiteheadp ; q ; aswhiteh@mail.med.upenn.edu" class="auth_mail" title="E-mail the corresponding author ; Stephen J. Chanockb ; 1 ; chanocks@mail.nih.gov" class="auth_mail" title="E-mail the corresponding author ; Curtis C. Harrisf ; 1 ; Curtis_Harris@nih.gov" class="auth_mail" title="E-mail the corresponding author
- 关键词：Genome-wide association study ; Lung neoplasms ; Smoking ; African Americans ; Telomerase ; Receptors ; Cholinergic
- 刊名：Lung Cancer
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：98
- 期：Complete
- 页码：33-42
- 全文大小：1596 K
文摘
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Confirmed previous reports that two loci on 15q25.1 and 5p15.33 are associated with lung cancer.
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Two loci associated with lung cancer are near plausible candidate genes, CHRNA5 and TERT.
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No SNPs reached genome-wide significance for the main effect model examining cigarettes per day.