Sentinel Lymph Node Biopsy After Neoadjuvant Chemotherapy in Patients With an Initial Diagnosis of Cytology-Proven Lymph Node-Positive Breast Cancer

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• 作者：Katsutoshi Enokido¹ ; ^{katsueno@hotmail.co.jp" class="auth_mail" title="E-mail the corresponding author} ; Chie Watanabe¹ ; Seigo Nakamura¹ ; Akiko Ogiya² ; Tomo Osako³ ; Futoshi Akiyama³ ; Akiyo Yoshimura⁴ ; Hiroji Iwata⁴ ; Shinji Ohno⁵ ; Yasuyuki Kojima⁶ ; Koichiro Tsugawa⁶ ; Kazuyoshi Motomura⁷ ; Naoki Hayashi⁸ ; Hideko Yamauchi⁸ ; Nobuaki Sato⁹
• 关键词：Axillary lymph node dissection ; Breast cancer ; False negative ; Lymph node metastasis ; Sentinel node biopsy
• 刊名：Clinical Breast Cancer
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：16
• 期：4
• 页码：299-304
• 全文大小：366 K

文摘

Sentinel lymph node biopsy (SNB) is the standard treatment of node-negative breast cancer; however, whether SNB should be performed for patients with node-positive disease before neoadjuvant chemotherapy (NAC) is controversial. We evaluated the accuracy of SNB after NAC in patients with breast cancer with nodal metastasis before chemotherapy to determine the false-negative rate (FNR) and detection rate for SNB.

Patients and Methods

In the present multicenter prospective study performed from September 2011 to April 2013, 143 patients with breast cancer and positive axillary nodes, proved by fine needle aspiration cytology at the initial diagnosis (stage T1-T3N1M0), were enrolled. All patients underwent breast surgery with SNB and complete axillary lymph node dissection.

Results

After NAC, the pathologic complete nodal response rate was 52.4%. The sentinel lymph node could be identified in 130 cases (90.9%); the FNR was 16.0% (13 of 81). The FNR of each clinical subtype was 42.1% (8 of 19) for the estrogen receptor-positive and human epithelial growth factor 2 (HER2)-negative (luminal type), 16.7% (2 of 12) for ER-positive and HER2-positive (luminal-HER2 type), 3.2% (1 of 31) for HER2-positive (HER2-enriched type), and 10.5% (2 of 19) for ER-negative and HER2-negative (triple-negative breast cancer; P = .003). The FNR was significantly greater in the luminal than in the nonluminal type (odds ratio, 9.91; 95% confidence interval, 6.77-14.52).

Conclusion

SNB after NAC in patients with initially node-positive breast cancer was technically feasible but should not be recommended for the luminal subtype. However, the tumor subtype can guide patient selection, and axillary lymph node dissection could be omitted for the luminal-HER2, HER2-enriched, and triple-negative breast cancer subtypes.