Eukaryotic translation initiation factors in cancer development and progression

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• 作者：Rita Spilka ; Christina Ernst ; Anita Kuldeep Mehta ; Johannes Haybaeck
• 关键词：Eukaryotic initiation factors ; Translation initiation ; Cancer
• 刊名：Cancer Letters
• 出版年：2013
• 出版时间：28 October, 2013
• 年：2013
• 卷：340
• 期：1
• 页码：9-21
• 全文大小：1433 K

文摘

Eukaryotic gene expression is a complicated process primarily regulated at the levels of gene transcription and mRNA translation. The latter involves four main steps: initiation, elongation, termination and recycling. Translation regulation is primarily achieved during initiation which is orchestrated by 12 currently known eukaryotic initiation factors (eIFs). Here, we review the current state of eIF research and present a concise summary of the various eIF subunits. As eIFs turned out to be critically implicated in different oncogenic processes the various eIF members and their contribution to onset and progression of cancer are featured.