Expanding the scope of silane-mediated hydrodehalogenation reactions

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• 作者：Gary M. Noonan ; Barry R. Hayter ; Andrew D. Campbell ; Timothy W. Gorman ; Benjamin E. Partridge ; Gill M. Lamont
• 关键词：Hydrodehalogenation ; Palladium catalysed ; Silane
• 刊名：Tetrahedron Letters
• 出版年：2013
• 出版时间：21 August, 2013
• 年：2013
• 卷：54
• 期：34
• 页码：4518-4521
• 全文大小：2029 K

文摘

A palladium-catalysed, silane-mediated hydrodehalogenation (HDH) reaction with increased substrate scope has been developed. Whereas previous attempts to reduce carboxylic acid or phenol-containing aryl halides using silane-based HDH conditions failed, the current protocol allows efficient access to the reduced products. Chemoselective HDH in the presence of sensitive functional groups is also presented.