Hepatitis C virus inhibits CD4 T cell function via binding to Toll-like receptor 7

详细信息    查看全文

• 作者：Dalila Mele^a ; ^{d.mele@smatteo.pv.it} ; Stefania Mantovani^a ; ^{s.mantovani@smatteo.pv.it} ; Barbara Oliviero^a ; ^{b.oliviero@smatteo.pv.it} ; Giulia Grossi^a ; ^{g.grossi@smatteo.pv.it} ; Serena Ludovisi^c ; ^{serena.ludovisi@humanitas.it} ; Mario U. Mondelli^a ; ^b ; ^{mario.mondelli@unipv.it} ; Stefania Varchetta^a ; ^{s.varchetta@smatteo.pv.it}
• 关键词：TLR7 ; CD4 ; HCV ; IRS661 ; Imiquimod
• 刊名：Antiviral Research
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：137
• 期：Complete
• 页码：108-111
• 全文大小：895 K
• 卷排序：137

文摘

Agonistic engagement of TLR7 reduces CD4 T cell functional activity. Hepatitis C virus (HCV) inhibits CD4 T-cell IL2 and interferon γ production and expression of activation markers. A TLR7 inhibitory oligonucleotide sequence reverts HCV-induced CD4 T cell anergy. Viral RNA binding to TLR7 may be a general mechanism of RNA virus evasion from host's adaptive immunity. The use of TLR7 agonists to treat chronic RNA virus infections could be counter-productive.