Dihydroxylated E,E,Z-docosatrienes. An overview of their synthesis and biological significance
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- 作者：Laurence Balas ; laurence.balas@umontpellier.fr" class="auth_mail" title="E-mail the corresponding author ; Thierry Durand
- 关键词：10 ; 17-diHDHEAEZE ; 10 ; 17-dihydroxydocosahexaenoyl ethanolamide i.e. ethanolamide derivative of PDX ; 10-epi-PD1 ; epimer of the molecule PD1 at carbon atom 10 ; 14(S)-HpDHA ; 14(S)-hydroperoxy docosahexaenoic acid ; 14-HDHA ; 14(S)-hydroxy docosahexaenoic acid ; 17(S)-HpDHA ; 17(S)-hydroperoxideDHA ; AdA ; adrenic acid (C22 ; 4 n ; &minus ; ; 6) ; ALOX15 ; 15-lipoxygenases 15 ; AT ; aspirin-triggered ; BAL ; broncho-alveolar lavage ; BIRC3 ; baculoviral inhibitor-of-apoptosis repeat containing protein 3 ; cAMP
- 刊名：Progress in Lipid Research
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：61
- 期：Complete
- 页码：1-18
- 全文大小：1030 K
文摘
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An update of the biological properties of several protectins is given.
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The different strategies to obtain E,E,Z-trienes flanked by hydroxyls are reviewed.
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Docosatrienes are involved in the inflammation and virus replication processes.
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Newly discovered endogenous docosatrienes are presented.
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Interestingly, PD1 and MaR1 interfere with the (innate) immune system.