Mitochondrial stress induces cellular senescence in an mTORC1-dependent manner
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- 作者：Timothy Nacarelli ; Ashley Azar ; Christian Sell ; christian.sell@drexelmed.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Free Radical Biology and Medicine
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：95
- 期：Complete
- 页码：133-154
- 全文大小：4684 K
文摘
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Low level ROS leads to mTORC1 activation, high levels of ROS inhibit mTORC1 through AMPK.
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mTORC1/S6 kinase activity can target HDM2 following mitochondrial dysfunction to activate p53.
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Changes in mTORC1 activity alter oxygen consumption rates and are tied to energy status.
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Elevated mTORC1 activity may represent a chronic stress response leading to senescence.