刊名:Biochemical and Biophysical Research Communications
出版年:2017
出版时间:1 January 2017
年:2017
卷:482
期:1
页码:188-194
全文大小:862 K
卷排序:482
文摘
HER2-positive BCA cells overexpress Ca2+-activated Cl− channel ANO1. HER2-positive BCA YMB-1 cells are resistant to trastuzumab. ANO1 inhibition induces transcriptional repression of HER2 in YMB-1 cells. HDAC3 inhibition induces transcriptional repression of HER2 via ANO1 in YMB-1 cells. ANO1 inhibition does not affect IGFBP5 transcription in YMB-1 cells.