Detection of the HE4 protein in urine as a biomarker for ovarian neoplasms

详细信息    查看全文

• 作者：Ingegerd Hellstrom ; Patrick J. Heagerty ; Elizabeth M. Swisher ; Pu Liu ; Jade Jaffar ; Kathy Agnew ; Karl Erik Hellstrom
• 关键词：ELISA ; Ovarian cancer diagnostics ; Urine ; HE4
• 刊名：Cancer Letters
• 出版年：2010
• 出版时间：1 October 2010
• 年：2010
• 卷：296
• 期：1
• 页码：43-48
• 全文大小：301 K

文摘

The HE4 protein is overexpressed in ovarian carcinomas and can be detected in serum by an ELISA with sensitivity similar to CA125 and higher specificity for malignant disease. We now demonstrate that HE4 can also be detected in the urine at a specificity level of 94.4 % , including 13/15 (86.6 % ) with stage I/II and 57/64 (89.0 % ) with stage III/IV disease and including 90.5 % of patients with serous ovarian carcinoma. Assaying serum and urine from the same patients showed similar sensitivity. Our data indicate that measuring HE4 in urine may aid diagnosis and the monitoring of response to therapy.